For me, there’s only one round I’d carry for self defense in .22lr: CCI Mini-mag 40 grain round nose. In a handgun, I need reliability and in a .22 I need penetration. The Mini-mag is about as good as it gets.
I have carried .22 before. I really like my Ruger LCP II in .22LR. I run Federal Punch ammo when I do.
The Velocitor is the same 40 gr hp as the MiniMag with more speed for better penetration.
I haven’t tested that round, so cannot endorse.
Of course there’s the “Lies, Damm Lies, and Statistics” saw to get around.
Was it because the assailant was point blank, knowing the firearm and underestimating it, leaving themselves completely open to a critical shot? Blind, Stupid Luck? Because it really IS a cartridge that performs way above its weight class?
Who really knows.
I’m actually getting something chambered in .22wmr for my Sister to carry for her Defense (she’s just too recoil-sensitive for even.380). It’s on order right now, maybe even already at my FFL.
Note the Hornady Critical Defense and the Speer results in Ballistic Gel.
I bought my Dad a box of those Hornady Critical Defense Rounds.
@Simple_Man I didnt know that, and im sorry for your loss. another thing about .22 is it tends to enter the body and bounce around off of things.. which makes it even more lethal.
I’ve carried it before long ago as well and all i’ve used when i did carry .22 was CCI so i agree with you.
I just watched a Paul Harrell video last night addressing barrel length specifically concerning.22lr velocity and accuracy. He demonstrated firing thru a Ruger 10-22 (16.5"), and 2 Marlin 60’s with barrel lengths of 18.5 and 22".
The first issue was the typical barrel length vs muzzle velocity. Normally longer equals faster due to more acceleration time in the barrel. However, he made the point that the .22lr cartridge is small and completely expends it’s power before the bullet reaches the muzzle. He said therefore if the barrel is too long on a .22lr - once the gas has fully expanded, extra barrel length will create drag and decelerate the bullet.
He then goes on to prove it with a chronograph and the 22" barrel does have slower muzzle velocity than the shorter barreled rifles. Henry offers a 24" barrel. I’m glad that I didn’t select it, now for two reasons. One, now that I know it slows bullet down, and two, it would add at least another pound to the rifle. The classic weighs about 5.5 lbs. Mine, with 20" octagon barrel weighs 6.5 lbs. The 24" octagon barrel has to be about 7.5 lbs. (However the 24" .22 WMR or .17 HMR may benefit from the longer length)
But I will shut up now, here’s the 
I knew I didn’t like Remington Gold 
Good video though, guy seems a bit crazy but I like him.
He was well respected for his knowledge of firearms, sadly he is no longer with us, he lives on in legend and his videos.
I think you’ll like this character too - NOT .22lr 
Word on the street is .22’s love to bounce around once inside the body. One of the reasons why they are so deadly, especially if they enter the skull, they generally lack the power to exit it.
I always liked Paul because he wasn’t trying to force his view on you, just give you some info, a sprinkling of opinion, and then real world demonstrations. Same with Hickock45, I love it when old heads just wanna share what they know with the rest of us.
I only had one ftf out of 400 rounds with CCiMM’s gonna chalk that up to a dirty .22 pistol.
I have 0 experience with 22wmr some people say it’s a slightly punchier dirtier .22.
But also some claim it has the performance of a larger round 
personally I don’t want to pay 9mm prices for a .22 so I’ve stayed away.
I have the 22” barrel.
That is I think the dirtiest ammo I have ever shot.
He was at The Gathering this year iirc.
Yes
I prefer to shoot it at matches over anything else. I’ve had less stoppages than even the CCI. maybe I’ve been lucky, I dunno.
I won’t even shoot the rest of the Aguila I have in the can, IT’S so dirty. I give them props for making .22lr during the Crovidy when nobody else was - but it’s the last I will shoot if ever I run out again.