21C (a 220 grain Hard Cast plain based LFN) is the absolute heaviest bullet that can be fired through 10mm pistols. With its flat nose, it will penetrate straight and very deeply into muscle and bone. Straight line penetration into living tissue will exceed three feet.

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Buffalo Bore Outdoorsman 10mm Auto 220 grain Hard Cast Flat Nose Handgun Ammo, 20/Box - 21C/20